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Anastrozole uses in bodybuilding. When male athletes use anabolic steroids, some of them convert by the aromatase enzyme into the female hormone estradiol (aromatization). The most aromatizing steroids are testosterone esters and methandienone. If estradiol is not inhibited by taking aromatase inhibitors (AI), unpleasant side effects may occur. The most common of them is gynecomastia, i.e. the build-up of female breast tissue in men under the impact of female hormone estradiol. Estradiol also causes water retention and an increase in the amount of subcutaneous fat. As a result, you can get a rise in blood pressure, heart strain, and depression. High levels of estradiol may adversely affect libido.
On the other hand, anastrozole in high quantities or stronger aromatase inhibitors can suppress estradiol too much. As a result, we can expect as well as erectile dysfunction, loss of energy, depression.
The main advantage of anastrozole as compared to antiestrogens (SARMs) such as tamoxifen or clomiphene consists in the fact that anastrozole blocks production of the aromatase enzyme, hence, prevents estradiol generation at the earliest stages, while antiestrogens only prevent contact of estradiol with the corresponding receptors by binding to them instead of estradiol, but don’t reduce its production in the body. Therefore, estradiol may still circulate in the bloodstream in large amounts when you take antiestrogens.